GAED Medal Lecture 2022: Challenging the Dogma in Diabetic Neuropathy and Beyond

The Sir David Cuthbertson Medal Lecture 1991

The effect of date aqua extract and melatonin on diabetic neuropathy in STZ-induced diabetic rats

Introduction: Diabetes mellitus is often associated with chronic neuropathy, a condition which is due to the disturbance in the function of peripheral nervous system. Studying the effects of antioxidants in relieving neuropathy is of a great clinical importance. The aim of this study was to compare the effect of aqua extract of date and Melatonin in preventing neuropathic hyperalgesia in Strept...

Endocrine Disrupting Contaminants—Beyond the Dogma

Descriptions of endocrine disruption have largely been associated with wildlife and driven by observations documenting estrogenic, androgenic, antiandrogenic, and antithyroid actions. These actions, in response to exposure to ecologically relevant concentrations of various environmental contaminants, have now been established in numerous vertebrate species. However, many potential mechanisms an...

IκBα beyond the NF-kB dogma

The NF-κB pathway participates in a myriad of processes including cell differentiation, proliferation, survival, and regulation of the immune response. In mammals there are five NF-κB proteins: p65/RelA, p50, RelB, cRel and p52. All these proteins can form dimers to generate more than a dozen of possible combinations. Different NF-κB dimers bind the DNA at specific κB sites, acting as activator...

Echinococcus, Giardia and Cryptosporidium: observational studies challenging accepted dogma.

The development of in vitro culture systems that allow the maintenance, and support the development of Echinococcus, Giardia and Cryptosporidium in the laboratory have had a significant impact on their biology and taxonomy and the epidemiology of infections they cause. This short retrospective review demonstrates how radical shifts in our understanding have occurred as a result of being able to...